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durabolin 25

As a weak base, blocks Na + channels inhibits the generation of pulses in the endings of the sensory nerves and the conduction of impulses along nerve fibers. Changes durabolin 25 the action potential in the membranes of nerve cells without the expressed influence on the resting potential. It suppresses holding not only the pain but also other pulses. Modalities. When the suction and direct intravascular injection reduces the excitability of peripheral cholinergic receptors decreases the formation and release of acetylcholine from preganglionic endings (ganglioblokiruyuschim has some effect), it removes spasm of smooth muscle, reduces the excitability of the myocardium and motor areas of the cerebral cortex.When administered intravenously, has analgesic, anti-hypertensive and anti-arrhythmic effects (increases the effective refractory period, reduces the excitability, automatism and conductivity), may interfere with neuromuscular conductivity at high doses.

Eliminates the descending inhibitory influences of the reticular formation of the brain stem. It inhibits polisinapticheskie reflexes. In large doses can cause convulsions. It has a short anesthetic activity (duration of infiltration anesthesia is 0,5-1ch).

The degree of absorption depends on the place (the degree of vascularization and blood flow in the introduction), the route of administration and total dosage. Rapidly hydrolyzed plasma and liver esterases to form 2 major pharmacologically active metabolites: dietilaminoetonola (possesses moderate vasodilatory action) and para-amino benzoic acid (a competitive antagonist of sulfa drugs and chemotherapy may weaken their antimicrobial action) .Period half-life of 30-50 seconds, neonotalnom period from -54-114. It is shown mainly kidneys as metabolites appears no more than 2% of unchanged.

Indications

  • infiltration, conduction and epidural anesthesia;
  • vagosympathetic neck, perirenal, circular and paravertebral blockade.

 

Contraindications:
Hypersensitivity (including para-amino benzoic acid and other local anesthetics), children up to 12 years.
For the creeping infiltration anesthesia method: marked fibrotic changes in the tissues. For epidural anesthesia: atrioventricular block, marked reduction in blood pressure, shock, infection venue lumbar puncture, septicemia.

Precautions
Emergency operation, accompanied by acute blood loss; condition associated with decreased hepatic blood flow (such as in chronic heart failure, liver diseases); pseudocholinesterase durabolin 25 deficit; renal failure;Children age 12 to 18 years and in elderly patients (65 years); debilitated patients; pregnancy and childbirth.

Side effects:
headache, dizziness, drowsiness, weakness, cauda equina syndrome, convulsions, increased or decreased blood pressure, collapse, peripheral vasodilatation, bradycardia, arrhythmia, chest pain, involuntary urination or defecation, impotence, infants, allergic reactions (up to anaphylactic shock).
From the digestive system: nausea, vomiting.
Other: the return of pain, persistent anesthesia, hypothermia, anesthesia in dentistry: numbness and paresthesias of the lips and tongue, elongation anesthesia.

Overdose
symptoms: pale skin and mucous membranes. Dizziness, nausea, vomiting, a “cold” sweat, increased severity of side effects. Treatment: maintenance of adequate pulmonary ventilation, detoxification therapy, and sympathetic.

Interaction
dampening effect on the central nervous system of means for general anesthesia, hypnotics and sedatives, narcotic analgesics and tranquilizers.
When using mestnoanesteziruyuschih drugs for spinal and epidural anesthesia guanadrel, guanethidine, mecamylamine, trimetafanom, increases the risk of a sharp decline in blood pressure and bradycardia .
Anticoagulants (ardeparin, dalteparin, danaparoid, enoxaparin, heparin, warfarin) increase the risk of bleeding. When applied to the site of injection of local anesthetic disinfectant solutions containing heavy metals, increases the risk of local reactions such as pain and swelling.
The use of MAO inhibitors (furazolidone, procarbazine, selegelin) increases the risk of hypotension.
Strengthen and lengthen the effect of muscle relaxants.
In appointing co procaine narcotic analgesics notes “additive effect that is used during spinal and epidural anesthesia, with enhanced respiratory depression.
Vasoconstrictors (epinephrine, methoxamine, phenylephrine) extend mestnoanesteziruyuschee effect.
Procaine reduces antimiastenicheskoe effects of drugs, especially when used in high doses, which requires additional correction treatment of myasthenia gravis.
cholinesterase inhibitors (antimiastenicheskie the JIC, cyclophosphamide, demekarin, ekotiofat, thiotepa) decrease the metabolism of procaine.
metabolite procaine (para-aminobenzoic acid) is an antagonist of sulfonamides.

Cautions
Patients need to control the functions of the cardiovascular, respiratory and central nervous systems. You must undo the MAO inhibitors within 10 days prior to administration of a local anesthetic. In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities durabolin 25 that require high concentration and psychomotor speed reactions. Before applying the mandatory tests on individual sensitivity to the drug. It is necessary to consider that during the use of topical anesthesia in the same total dose, novocaine toxicity is higher, the more concentrated solution was used.Not absorbed by the mucous membranes; It does not provide surface anesthesia in cutaneous application.

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